Bmi1^{tm1(cre/ERT)Mrc}
Targeted Allele Detail

Summary

• Symbol: Bmi1^{tm1(cre/ERT)Mrc}
• Name: Bmi1 polycomb ring finger oncogene; targeted mutation 1, Mario R Capecchi
• MGI ID: MGI:3805814
• Synonyms: Bmi1^CreER, Bmi1^{tm1(cre/ESR1)Mrc}
• Gene: Bmi1 Location: Chr2:18681953-18691440 bp, + strand Genetic Position: Chr2, 12.9 cM
• Alliance: Bmi1^{tm1(cre/ERT)Mrc} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:138364
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Bmi1^{tm1(cre/ERT)Mrc} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Bmi1 (MGI:88174)

• Mutation details: An IRES followed by a cre/ERT fusion and an frt-flanked neo cassette was inserted downstream of the translation stop codon. Germ line, flp-mediated recombination was used to remove the neo cassette. (J:138364)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Bmi1 (mouse) Summary of all recombinase alleles driven by Bmi1. Comparative matrix view of recombinase activities Alliance mouse Bmi1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Bmi1 Mutation: 31 strains or lines available

References

• Original: J:138364 Sangiorgi E, et al., Bmi1 is expressed in vivo in intestinal stem cells. Nat Genet. 2008 Jul;40(7):915-20
• All: 47 reference(s)