Spink1^tm2Kymm
Targeted Allele Detail

Summary

• Symbol: Spink1^tm2Kymm
• Name: serine peptidase inhibitor, Kazal type 1; targeted mutation 2, Ken-ichi Yamamura
• MGI ID: MGI:3805845
• Synonyms: Spink3^lacZ
• Gene: Spink1 Location: Chr18:43861134-43870302 bp, - strand Genetic Position: Chr18, 23.47 cM, cytoband B3
• Alliance: Spink1^tm2Kymm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:138347
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A cassette containing lacZ gene and frt-flanked puromycin gene and encompassed by a 5' loxJTZ17 site and a 3' lox2272 site was inserted upstream of exon 1. Targeted recombination was performed in cells already containing Spink3^tm1Kymm replacing its neo cassette. (J:138347, J:205182)

Expression

In Mice Carrying this Mutation:

47 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Spink1 Mutation: 14 strains or lines available

References

• Original: J:138347 Wang J, et al., Expression pattern of serine protease inhibitor kazal type 3 (Spink3) during mouse embryonic development. Histochem Cell Biol. 2008 Aug;130(2):387-97
• All: 2 reference(s)