Tg(MC1R)1Jkn
Transgene Detail

Summary

• Symbol: Tg(MC1R)1Jkn
• Name: transgene insertion 1, Ian J Jackson
• MGI ID: MGI:3805878
• Synonyms: Tg-MC1R
• Transgene: Tg(MC1R)1Jkn Location: unknown
• Alliance: Tg(MC1R)1Jkn page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(MC1R)1Jkn expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MC1R (4157)

  Mc1r	(MGI:99456)

• Mutation details: The transgene strain was created by microinjection of the human BAC RPCI11-566K11 into embryos homozygous for Mc1r^e. The BAC contains 146 kb of sequence with the complete human gene MC1R and includes at least 4 other genes. Quantitative RT-PCR on skin samples indicated that expression of the human MC1R was 9- to 20-fold lower than the endogenous mouse gene. (J:129904)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:129904 Jackson IJ, et al., Humanized MC1R transgenic mice reveal human specific receptor function. Hum Mol Genet. 2007 Oct 1;16(19):2341-8
• All: 2 reference(s)