Smad1^tm1Tako
Targeted Allele Detail

Summary

• Symbol: Smad1^tm1Tako
• Name: SMAD family member 1; targeted mutation 1, Takashi Kobayashi
• MGI ID: MGI:3805956
• Gene: Smad1 Location: Chr8:80065024-80126057 bp, - strand Genetic Position: Chr8, 37.56 cM
• Alliance: Smad1^tm1Tako page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:79513
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The exon encoding part of the MH1 domain and linker region was replaced with a lacZ and neo cassette. The absence of transcript was confirmed by RT-PCR analysis on E7.5 total embryo extracts. (J:79513)

Expression

In Mice Carrying this Mutation:

39 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Smad1 Mutation: 32 strains or lines available

References

• Original: J:79513 Hayashi K, et al., SMAD1 signaling is critical for initial commitment of germ cell lineage from mouse epiblast. Mech Dev. 2002 Oct;118(1-2):99
• All: 4 reference(s)