Hr^m1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Hr^m1Btlr
• Name: lysine demethylase and nuclear receptor corepressor; mutation 1, Bruce Beutler
• MGI ID: MGI:3805975
• Synonyms: prune
• Gene: Hr Location: Chr14:70789652-70810988 bp, + strand Genetic Position: Chr14, 36.32 cM
• Alliance: Hr^m1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: The prune mutation, discovered among G3 progeny of an ENU-mutagenized male mouse, corresponds to a T-to-G transversion at nucleotide position 3938 of the gene (Genbank: NM__021877), in exon 18 of 20 total exons. It results in replacement of a highly-conserved tyrosine by aspartic acid at amino acid 1082 of the protein (Y1082D). (J:138686)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hr Mutation: 87 strains or lines available

References

• Original: J:138686 Siggs OM, et al., Record for "prune", updated 2nd of September, 2008. MGI Direct Data Submission. 2008
• All: 1 reference(s)