Tg(H2-L-IL6)1Kish
Transgene Detail

Summary

• Symbol: Tg(H2-L-IL6)1Kish
• Name: transgene insertion 1, Tadamitsu Kishimoto
• MGI ID: MGI:3806003
• Synonyms: H-2L^d-hIL6 tg, IL-6 tgm, L^d-IL-6
• Transgene: Tg(H2-L-IL6)1Kish Location: unknown Genetic Position: Chr9, Syntenic
• Alliance: Tg(H2-L-IL6)1Kish page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(H2-L-IL6)1Kish expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  IL6 (3569)

  Il6	(MGI:96559)

• Mutation details: A transgenic construct containing the human IL6 gene and rabbit beta-globin sequence under the control of the mouse H-2L^d promoter was injected into fertilized C57BL/6 mouse eggs. Human IL6 protein is detected in serum by ELISA. mRNA is detected in the spleen, lymph nodes, thymus, heart, lung, liver, kidney, and intestine, but not in brain tissue. (J:40405, J:138762)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

Phenotypic Similarity to Human Syndrome: Multicentric Castleman Disease J:128016

References

• Original: J:138762 Kishimoto T, Generation of H2-L-IL6 transgenic mice. MGI Direct Data Submission. 2008
• All: 7 reference(s)