Padi6^tm1.1Jgo
Targeted Allele Detail

Summary

• Symbol: Padi6^tm1.1Jgo
• Name: peptidyl arginine deiminase, type VI; targeted mutation 1.1, Jan A Gossen
• MGI ID: MGI:3806009
• Gene: Padi6 Location: Chr4:140454666-140469954 bp, - strand Genetic Position: Chr4, 72.26 cM, cytoband E1
• Alliance: Padi6^tm1.1Jgo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:138684
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Germ line, cre-mediated recombination was used to remove exons 2 and 3. The absence of protein expression was confirmed by immunohistochemistry on ovaries. (J:138684)

Expression

In Mice Carrying this Mutation:	8 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Padi6 Mutation: 32 strains or lines available

References

• Original: J:138684 Esposito G, et al., Peptidylarginine deiminase (PAD) 6 is essential for oocyte cytoskeletal sheet formation and female fertility. Mol Cell Endocrinol. 2007 Jul 15;273(1-2):25-31
• All: 4 reference(s)