Atp7a^Mo-2Btlr
Chemically induced Allele Detail

Summary

• Symbol: Atp7a^Mo-2Btlr
• Name: ATPase, copper transporting, alpha polypeptide; mottled 2 Bruce Beutler
• MGI ID: MGI:3806010
• Synonyms: Atp7a^Tigrou, Tigrou
• Gene: Atp7a Location: ChrX:105070882-105168532 bp, + strand Genetic Position: ChrX, 47.36 cM
• Alliance: Atp7a^Mo-2Btlr page

Coat color phenotypes of mutants carrying the Atp7a^Mo-Btlr, Atp7a^Mo-2Btlr, or Atp7a^Mo-3Btlr allele

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: The Tigrou mutation, discovered in a G1 daughter of an ENU-mutagenized male mouse, corresponds to a G-to-T transversion at nucleotide position 1485 of the gene, in the fifth of 23 total exons. It results in replacement of the glutamic acid codon at position 469 by a stop codon (E469Ter), which would truncate the protein before the fifth metal binding domain. It is unknown whether this truncated protein is expressed in mutant mice. (J:138687, J:188598)
• Inheritance: Semidominant

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Atp7a Mutation: 69 strains or lines available

References

• Original: J:138687 Du X, et al., Record for "Tigrou" updated 2nd of June, 2008. MGI Direct Data Submission. 2008
• All: 2 reference(s)