Drosha^tm1.1Litt
Targeted Allele Detail

Summary

• Symbol: Drosha^tm1.1Litt
• Name: drosha, ribonuclease type III; targeted mutation 1.1, Dan R Littman
• MGI ID: MGI:3806089
• Synonyms: Drosha^del, Drosha^delta
• Gene: Drosha Location: Chr15:12824901-12935377 bp, + strand Genetic Position: Chr15, 5.99 cM
• Alliance: Drosha^tm1.1Litt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:138683
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was used to introduce a loxP-flanked neomycin resistance cassette to intron 8, and an additional loxP site to intron 9 of the gene. The mice were crossed with a C57BL/6 background EIIa-Cre line, deleting exon 9 (and the neo cassette). (J:138683)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Drosha Mutation: 96 strains or lines available

References

• Original: J:138683 Chong MM, et al., The RNAseIII enzyme Drosha is critical in T cells for preventing lethal inflammatory disease. J Exp Med. 2008 Sep 1;205(9):2005-17
• All: 5 reference(s)