Tg(RHO-VEGFA)V-6Camp
Transgene Detail

Summary

• Symbol: Tg(RHO-VEGFA)V-6Camp
• Name: transgene insertion V-6,Peter A Campochiaro
• MGI ID: MGI:3806310
• Synonyms: rho/VEGF, Tg (bRhdopsin-hVEGF-165) 6Pac, V-6
• Transgene: Tg(RHO-VEGFA)V-6Camp Location: unknown
• Alliance: Tg(RHO-VEGFA)V-6Camp page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(RHO-VEGFA)V-6Camp expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  VEGFA (7422)

  Vegfa

  (MGI:103178)

• Mutation details: This transgene consists of a 2.2 kb fragment of the bovine rhodopsin promoter driving expression of a full length human VEGFA cDNA followed by an intron and polyA site from the mouse protamine gene. Three to four copies of the transgene were incorporated in this line. A strong mRNA signal is seen in the retina of hemizygous mice at 1 month of age. (J:41411)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:41411 Okamoto N, et al., Transgenic mice with increased expression of vascular endothelial growth factor in the retina: a new model of intraretinal and subretinal neovascularization [see comments]. Am J Pathol. 1997 Jul;151(1):281-91
• All: 23 reference(s)