Tal1^tm1(tTA)Bock
Targeted Allele Detail

Summary

• Symbol: Tal1^tm1(tTA)Bock
• Name: T cell acute lymphocytic leukemia 1; targeted mutation 1, Ernesto Bockamp
• MGI ID: MGI:3806344
• Synonyms: SCL^tTA-2S, SCL-tTA-S2
• Gene: Tal1 Location: Chr4:114913623-114928952 bp, + strand Genetic Position: Chr4, 52.73 cM
• Alliance: Tal1^tm1(tTA)Bock page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:138070
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Transactivator)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: All ATG codons in exon 4 and the first in exon 4 were modified to GGG codons to prevent translation initiation. A floxed neo cassette and the tTA-2S transactivator were inserted into exon 5. Germ line, cre-mdiated recombination was used to remove the neo cassette. (J:138070)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tal1 Mutation: 33 strains or lines available

References

• Original: J:138070 Bockamp E, et al., Tetracycline-controlled transgenic targeting from the SCL locus directs conditional expression to erythrocytes, megakaryocytes, granulocytes, and c-kit-expressing lineage-negative hematopoietic cells. Blood. 2006 Sep 1;108(5):1533-41
• All: 6 reference(s)