Gt(ROSA)26Sor^{tm1.1(PDGFB)Cbet}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1.1(PDGFB)Cbet}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1.1, Christer Betsholtz
• MGI ID: MGI:3806367
• Synonyms: Rosa26-Pdgf-b, Rosa26-PDGF-BB
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1.1(PDGFB)Cbet} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:138069
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1.1(PDGFB)Cbet} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  PDGFB (5155)

  Pdgfb

  (MGI:97528)

• Mutation details: The locus was used to drive ubiquitous expression of human PDGFB preceded by a floxed neo stop-sequence. Cre mediated recombination removed the stop-sequence. (J:138069)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 991 strains or lines available

References

• Original: J:138069 Rolny C, et al., Platelet-derived growth factor receptor-beta promotes early endothelial cell differentiation. Blood. 2006 Sep 15;108(6):1877-86
• All: 1 reference(s)