Id2^tm1Ago
Targeted Allele Detail

Summary

• Symbol: Id2^tm1Ago
• Name: inhibitor of DNA binding 2; targeted mutation 1, Ananda W Goldrath
• MGI ID: MGI:3806370
• Gene: Id2 Location: Chr12:25143798-25146091 bp, - strand Genetic Position: Chr12, 8.57 cM, cytoband B
• Alliance: Id2^tm1Ago page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:116119
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo cassette in reverse orientation replaced upstream untranslated sequence and the helix-loop-helix dimerization domain in exon 1. Northern blot and RT-PCR analysis confirmed the absence of expression in fetal liver and P7 thymi, respectively. (J:116119)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Id2 Mutation: 21 strains or lines available

References

• Original: J:116119 Cannarile MA, et al., Transcriptional regulator Id2 mediates CD8(+) T cell immunity. Nat Immunol. 2006 Dec;7(12):1317-25
• All: 6 reference(s)