Icam4^tm1Jach
Targeted Allele Detail

Summary

• Symbol: Icam4^tm1Jach
• Name: intercellular adhesion molecule 4, Landsteiner-Wiener blood group; targeted mutation 1, Joel Anne Chasis
• MGI ID: MGI:3806488
• Gene: Icam4 Location: Chr9:20940728-20941892 bp, + strand Genetic Position: Chr9, 7.69 cM, cytoband A3
• Alliance: Icam4^tm1Jach page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:138068
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 through 3 were replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis of erythrocyte extracts. (J:138068)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Icam4 Mutation: 8 strains or lines available

References

• Original: J:138068 Lee G, et al., Targeted gene deletion demonstrates that the cell adhesion molecule ICAM-4 is critical for erythroblastic island formation. Blood. 2006 Sep 15;108(6):2064-71
• All: 1 reference(s)