Gdf1^tm1Dmus
Targeted Allele Detail

Summary

• Symbol: Gdf1^tm1Dmus
• Name: growth differentiation factor 1; targeted mutation 1, Dmitry Usoskin
• MGI ID: MGI:3806582
• Synonyms: Gdf1^fl, Gdf1-flox
• Gene: Gdf1 Location: Chr8:70782467-70784237 bp, + strand Genetic Position: Chr8, 34.15 cM
• Alliance: Gdf1^tm1Dmus page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:138588
• Parent Cell Line: GSI-1 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2 and an frt flanked neo cassette with a 5' loxP site was inserted downstream of exon 2. Germ line, flp mediated recombination was used to remove the neo cassette leaving exon 2 floxed. (J:138588)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gdf1 Mutation: 8 strains or lines available

References

• Original: J:138588 Bengtsson H, et al., Generation and characterization of a Gdf1 conditional null allele. Genesis. 2008 Jul;46(7):368-72
• All: 3 reference(s)