Klf5^tm1Jaw
Targeted Allele Detail

Summary

• Symbol: Klf5^tm1Jaw
• Name: Kruppel-like transcription factor 5; targeted mutation 1, Jeffrey A Whitsett
• MGI ID: MGI:3806635
• Synonyms: Klf5^f, Klf5^loxP
• Gene: Klf5 Location: Chr14:99536127-99550848 bp, + strand Genetic Position: Chr14, 49.43 cM, cytoband E2.1
• Alliance: Klf5^tm1Jaw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:138576
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2 and an frt flanked neo cassette with a 3' loxP site was inserted downstream of exon 3. (J:138576)

Expression

In Mice Carrying this Mutation:	40 assay results 4 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	19 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Klf5^tm1Jaw

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Klf5 Mutation: 37 strains or lines available

References

• Original: J:138576 Wan H, et al., Kruppel-like factor 5 is required for perinatal lung morphogenesis and function. Development. 2008 Aug;135(15):2563-72
• All: 20 reference(s)