Spi1^tm1.1Rpd
Targeted Allele Detail

Summary

• Symbol: Spi1^tm1.1Rpd
• Name: Spi-1 proto-oncogene; targeted mutation 1.1, Rodney P DeKoter
• MGI ID: MGI:3806995
• Synonyms: Sfpi1^Blac
• Gene: Spi1 Location: Chr2:90912750-90946104 bp, + strand Genetic Position: Chr2, 50.44 cM, cytoband E3
• Alliance: Spi1^tm1.1Rpd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:138501
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Hypomorph, Reporter)
• Mutation: Insertion
• Mutation details: Germ line, cre mediated recombination was used to remove the neo cassette leaving the beta-lactamase intact. This is a hypomorphic allele. (J:138501)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Spi1 Mutation: 28 strains or lines available

References

• Original: J:138501 Kamath MB, et al., Dose-dependent repression of T-cell and natural killer cell genes by PU.1 enforces myeloid and B-cell identity. Leukemia. 2008 Jun;22(6):1214-25
• All: 1 reference(s)