Adam17^tm1Ckww
Targeted Allele Detail

Summary

• Symbol: Adam17^tm1Ckww
• Name: a disintegrin and metallopeptidase domain 17; targeted mutation 1, Colin K W Watt
• MGI ID: MGI:3807283
• Synonyms: Adam17^fl
• Gene: Adam17 Location: Chr12:21373510-21423633 bp, - strand Genetic Position: Chr12, 8.3 cM
• Alliance: Adam17^tm1Ckww page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:138782
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A novel exon was inserted between exons 11 and 12 with a STOP codon at the beginning of the exon. Authors state that this is a floxed allele with details to follow in a subsequent publication. Expression from this allele is 90% to 95% reduced from wild type. (J:138782)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adam17 Mutation: 64 strains or lines available

References

• Original: J:138782 West MA, et al., TLR ligand-induced podosome disassembly in dendritic cells is ADAM17 dependent. J Cell Biol. 2008 Sep 8;182(5):993-1005
• All: 1 reference(s)