Tg(H2-K-DUSP5)21Wjl
Transgene Detail

Summary

• Symbol: Tg(H2-K-DUSP5)21Wjl
• Name: transgene insertion 21, Warren J Leonard
• MGI ID: MGI:3807515
• Synonyms: Tg(H2-K-DUSP5)1Wjl
• Transgene: Tg(H2-K-DUSP5)21Wjl Location: unknown
• Alliance: Tg(H2-K-DUSP5)21Wjl page

Ulcerative dermatitis and kidney glomerular lesions in Tg(H2-K-DUSP5)21Wjl/0 mice

Show the 1 phenotype image(s) involving this allele.

Transgene origin

• Strain of Origin: (C57BL/6 x CBA)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(H2-K-DUSP5)21Wjl expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  DUSP5 (1847)

  Dusp5

  (MGI:2685183)

• Mutation details: A human DUSP5 cDNA with a C-terminal c-Myc epitope tag was cloned between the H2-K^b promoter and beta-blobin exons 2 and 3, a polyadenylation signal and an immunoglobin heavy chain enhancer. Protein expression was confirmed by western blotting. Two founder lines were produced. Data from only one representative line was reported. (J:138077)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:138077 Kovanen PE, et al., T-cell development and function are modulated by dual specificity phosphatase DUSP5. J Biol Chem. 2008 Jun 20;283(25):17362-9
• All: 1 reference(s)