Gpsm1^tm1.1Lajb
Targeted Allele Detail

Summary

• Symbol: Gpsm1^tm1.1Lajb
• Name: G-protein signalling modulator 1 (AGS3-like, C. elegans); targeted mutation 1.1, Stephen Lanier
• MGI ID: MGI:3807518
• Synonyms: Gpsm1^nullLajb
• Gene: Gpsm1 Location: Chr2:26205527-26238249 bp, + strand Genetic Position: Chr2, 18.73 cM, cytoband A3
• Alliance: Gpsm1^tm1.1Lajb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:138126
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed and Frted PGK-neo cassette was inserted on one side and a single loxP sites was inserted on the other side of a 410 bp fragment that included exon 3. Cre- and Flp-mediated recombination resulted in removal of exon 3. Immunoblot analysis confirmed the absence of full length protein expression in brains and hearts from homozygous mice. Expression of a short form in the heart is not disrupted in homozygotes. (J:138126)

Disease models

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gpsm1 Mutation: 42 strains or lines available

References

• Original: J:138126 Blumer JB, et al., Activator of G protein signaling 3 null mice: I. Unexpected alterations in metabolic and cardiovascular function. Endocrinology. 2008 Aug;149(8):3842-9
• All: 7 reference(s)