Tg(Nr2e1-cre/ERT2)1Gsc
Transgene Detail

Summary

• Symbol: Tg(Nr2e1-cre/ERT2)1Gsc
• Name: transgene insertion 1, Gunther Schutz
• MGI ID: MGI:3807544
• Synonyms: Tlx-CreER^T2
• Transgene: Tg(Nr2e1-cre/ERT2)1Gsc Location: unknown
• Alliance: Tg(Nr2e1-cre/ERT2)1Gsc page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Nr2e1-cre/ERT2)1Gsc expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Nr2e1

• Mutation details: This transgene consists of modified BAC containing the entire coding region of the Nr2e1 gene including flanking regulatory sequences 104 kb upstream and 30 kb downstream, and drives expression of a tamoxifen-inducible form of cre recombinase fusion protein which replaces part of exon 1 of the Nr2e1 gene. 6 lines were generated of which 3 lines are further analyzed. All three lines showed tamoxifen-inducible Cre activity in the developing forebrain. This is a representative record for all 3 lines. (J:138765)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Nr2e1 (species not specified) Summary of all recombinase alleles driven by Nr2e1. Comparative matrix view of recombinase activities

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:138765 Liu HK, et al., The nuclear receptor tailless is required for neurogenesis in the adult subventricular zone. Genes Dev. 2008 Sep 15;22(18):2473-8
• All: 6 reference(s)