Traf4^m1Pav
Chemically induced Allele Detail

Summary

• Symbol: Traf4^m1Pav
• Name: TNF receptor associated factor 4; mutation 1, William J Pavan
• MGI ID: MGI:3807561
• Synonyms: modifier of Sox10 expression pattern 2, msp2, Traf4^msp2
• Gene: Traf4 Location: Chr11:78049325-78056415 bp, - strand Genetic Position: Chr11, 46.74 cM, cytoband B5-C
• Alliance: Traf4^m1Pav page

Mutation origin

• Strain of Origin: BALB/cJ

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: This ENU mutation was identified in a screen for alteration in the neural crest expression pattern of the lacZ reporter allele Sox10 (Sox10^tm1Weg). The mutation has been reported to be a C to T transition in the 5' splice site of Traf4 intron 2 that results in skipping of exon 2. mRNA can be detected. (J:94077)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Traf4 Mutation: 37 strains or lines available

References

• Original: J:138775 Buac K, et al., A Sox10 expression screen identifies an amino acid essential for Erbb3 function. PLoS Genet. 2008 Sep;4(9):e1000177
• All: 2 reference(s)