Tg(KRT5-cre/ERT2)AJdg
Transgene Detail

Summary

• Symbol: Tg(KRT5-cre/ERT2)AJdg
• Name: transgene insertion A, John DiGiovanni
• MGI ID: MGI:3807716
• Transgene: Tg(KRT5-cre/ERT2)AJdg Location: unknown
• Alliance: Tg(KRT5-cre/ERT2)AJdg page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(KRT5-cre/ERT2)AJdg expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  cattle	KRT5 (281268)

• Mutation details: A DNA construct composed cre sequence and the human tamoxifen responsive estrogen receptor ligand-binding domain (ER^T2 was placed under the control of the bovine KRT5 promoter. Three founder lines were produced. Line A showed the highest inducible cre expression. (J:138529)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	KRT5 (cattle) Summary of all recombinase alleles driven by KRT5.

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:138529 Kataoka K, et al., Stage-specific disruption of Stat3 demonstrates a direct requirement during both the initiation and promotion stages of mouse skin tumorigenesis. Carcinogenesis. 2008 Jun;29(6):1108-14
• All: 7 reference(s)