Pth2^tm1Vlcg
Targeted Allele Detail

Summary

• Symbol: Pth2^tm1Vlcg
• Name: parathyroid hormone 2; targeted mutation 1, Velocigene
• MGI ID: MGI:3807987
• Synonyms: Tifp39^-, TIP39^-, TIP39-KO
• Gene: Pth2 Location: Chr7:44830419-44831262 bp, + strand Genetic Position: Chr7, 29.17 cM
• Alliance: Pth2^tm1Vlcg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:138142
• Parent Cell Line: F1H4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NTac)F1

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Both coding exons and the intervening intron were replace by a cassette containing beta-galactosidase and the neomycin resistance gene. The initiating methionine was replaced by that of the lacZ insert. (J:102090, J:138142)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pth2 Mutation: 4 strains or lines available

References

• Original: J:138142 Usdin TB, et al., Tuberoinfundibular Peptide of 39 residues is required for germ cell development. Endocrinology. 2008 Sep;149(9):4292-300
• All: 9 reference(s)