Tbx4^tm1.1Kng
Targeted Allele Detail

Summary

• Symbol: Tbx4^tm1.1Kng
• Name: T-box 4; targeted mutation 1.1, David M Kingsley
• MGI ID: MGI:3808010
• Synonyms: Tbx4 DelA, Tbx4^deltaHLEA
• Gene: Tbx4 Location: Chr11:85777248-85806923 bp, + strand Genetic Position: Chr11, 51.42 cM
• Alliance: Tbx4^tm1.1Kng page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:139169
• Parent Cell Line: CGR8 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Modified regulatory region)
• Mutations: Insertion, Intragenic deletion
• Germ line, cre mediated recombination was used to remove the upstream hindlimb enhancer A. (J:139169)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tbx4 Mutation: 23 strains or lines available

Notes

ES cell line = CGR8.8 (subline of CGR8)

References

• Original: J:139169 Menke DB, et al., Dual hindlimb control elements in the Tbx4 gene and region-specific control of bone size in vertebrate limbs. Development. 2008 Aug;135(15):2543-53
• All: 2 reference(s)