Hes1^tm1Kag
Targeted Allele Detail

Summary

• Symbol: Hes1^tm1Kag
• Name: hes family bHLH transcription factor 1; targeted mutation 1, Ryoichiro Kageyama
• MGI ID: MGI:3808031
• Synonyms: Hes1^f, Hes1^tm1Imayo
• Gene: Hes1 Location: Chr16:29883259-29886614 bp, + strand Genetic Position: Chr16, 21.09 cM
• Alliance: Hes1^tm1Kag page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:139170
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted after the first coding exon and a floxed neo cassette was inserted after the last coding exon. Expression of cre in ES cells was used to remove the neo cssette leaving coding exons 2 through 4 floxed. (J:139170)

Expression

In Mice Carrying this Mutation:

28 assay results

Tumor Data

List all tumor models in MMHCdb carrying Hes1^tm1Kag

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Hes1 Mutation: 23 strains or lines available

References

• Original: J:139170 Imayoshi I, et al., Hes genes and neurogenin regulate non-neural versus neural fate specification in the dorsal telencephalic midline. Development. 2008 Aug;135(15):2531-41
• All: 45 reference(s)