Tax1bp1^tm1Ktj
Targeted Allele Detail

Summary

• Symbol: Tax1bp1^tm1Ktj
• Name: Tax1 (human T cell leukemia virus type I) binding protein 1; targeted mutation 1, Kuan-Teh Jeang
• MGI ID: MGI:3808042
• Gene: Tax1bp1 Location: Chr6:52690714-52743765 bp, + strand Genetic Position: Chr6, 25.7 cM
• Alliance: Tax1bp1^tm1Ktj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:131849
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The translated region of exon 17 was replaced by a neomycin gene cassette. Western blot analysis indicated that no detectable protein was expressed from this allele. (J:131849)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tax1bp1 Mutation: 38 strains or lines available

References

• Original: J:131849 Iha H, et al., Inflammatory cardiac valvulitis in TAX1BP1-deficient mice through selective NF-kappaB activation. EMBO J. 2008 Feb 20;27(4):629-41
• All: 4 reference(s)