Egflam^tm1Tfir
Targeted Allele Detail

Summary

• Symbol: Egflam^tm1Tfir
• Name: EGF-like, fibronectin type III and laminin G domains; targeted mutation 1, Takahisa Furukawa
• MGI ID: MGI:3808156
• Synonyms: Pikachurin^-
• Gene: Egflam Location: Chr15:7235601-7427876 bp, - strand Genetic Position: Chr15, 3.5 cM
• Alliance: Egflam^tm1Tfir page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:138693
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1, which includes a start codon, was replaced with the PGK-neo cassette. The lack of expression in the mutant mouse retina was confirmed by northern blot and immunostaining. (J:138693)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Egflam Mutation: 60 strains or lines available

References

• Original: J:138693 Sato S, et al., Pikachurin, a dystroglycan ligand, is essential for photoreceptor ribbon synapse formation. Nat Neurosci. 2008 Aug;11(8):923-31
• All: 5 reference(s)