Krt16^{tm1(KOMP)Vlcg}
Targeted Allele Detail

Summary

• Symbol: Krt16^{tm1(KOMP)Vlcg}
• Name: keratin 16; targeted mutation 1, Velocigene
• MGI ID: MGI:3808273
• Synonyms: Krt16^tm1Vlcg
• Gene: Krt16 Location: Chr11:100136917-100139728 bp, - strand Genetic Position: Chr11, 63.44 cM
• Alliance: Krt16^{tm1(KOMP)Vlcg} page
• IMPC: Krt16 gene page

Mutation origin

• Mutant Cell Lines: 10501A-A5, 10501A-E2, 10501A-F2, 10501B-H1
• Germline Transmission: Earliest citation of germline transmission: J:184621
• Parent Cell Line: VGB6 (ES Cell)
• Strain of Origin: C57BL/6NTac
• Project Collection: KOMP-Regeneron

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion Vector: ZEN-Ub1
• Mutation details: The insertion of Velocigene cassette ZEN-Ub1 created a deletion of size 2674bp between positions 100137040-100139713 of Chromosome 11 (Build GRCm39). (J:136110)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 1 line available
• Carrying any Krt16 Mutation: 28 strains or lines available

Notes

Mutant cell lines 10501A-E2 and 10501B-H1 have been used to generate chimeras but failed to establish germline transmission.

References

• Original: J:136110 Velocigene, Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals). MGI Direct Data Submission. 2008
• All: 7 reference(s)