Prl3c1^{tm1(KOMP)Vlcg}
Targeted Allele Detail

Summary

• Symbol: Prl3c1^{tm1(KOMP)Vlcg}
• Name: prolactin family 3, subfamily c, member 1; targeted mutation 1, Velocigene
• MGI ID: MGI:3808306
• Synonyms: Prl3c1^tm1Vlcg
• Gene: Prl3c1 Location: Chr13:27380643-27387732 bp, + strand Genetic Position: Chr13, 12.32 cM
• Alliance: Prl3c1^{tm1(KOMP)Vlcg} page
• IMPC: Prl3c1 gene page

Mutation origin

• Mutant Cell Lines: 10539A-H5, 10539B-C7, 10539B-D10, 10539B-F4
• Germline Transmission: Earliest citation of germline transmission: J:256588
• Parent Cell Line: VGB6 (ES Cell)
• Strain of Origin: C57BL/6NTac
• Project Collection: KOMP-Regeneron

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion Vector: ZEN-Ub1
• Mutation details: The insertion of Velocigene cassette ZEN-Ub1 created a deletion of size 6904bp between positions 27380692-27387595 of Chromosome 13 (Build GRCm39). The entire coding sequence was replaced with an in-frame beta-galactosidase (lacZ) cassette (inserted at the ATG codon in the first exon) followed by a neomycin resistance cassette. (J:136110, J:256588)

Disease models

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 1 line available
• Carrying any Prl3c1 Mutation: 19 strains or lines available

Notes

Cell line 10539B-F4 was successfully used to make chimeric mice. Germline transmission was accomplished. J:256588

References

• Original: J:136110 Velocigene, Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals). MGI Direct Data Submission. 2008
• All: 2 reference(s)