Orm2^{tm1(KOMP)Vlcg}
Targeted Allele Detail

Summary

• Symbol: Orm2^{tm1(KOMP)Vlcg}
• Name: orosomucoid 2; targeted mutation 1, Velocigene
• MGI ID: MGI:3808483
• Synonyms: Orm2^tm1Vlcg
• Gene: Orm2 Location: Chr4:63280686-63284115 bp, + strand Genetic Position: Chr4, 33.96 cM
• Alliance: Orm2^{tm1(KOMP)Vlcg} page
• IMPC: Orm2 gene page

Mutation origin

• Mutant Cell Lines: 10770E-G12, 10770G-H1, 10770H-C1
• Germline Transmission: Earliest citation of germline transmission: J:292194
• Parent Cell Line: VGB6 (ES Cell)
• Strain of Origin: C57BL/6NTac
• Project Collection: KOMP-Regeneron

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion Vector: ZEN-Ub1
• Orm2^{tm1(KOMP)Vlcg} involves 2 genes/genome features (Orm1, Orm3) View all
• Mutation details: The insertion of Velocigene cassette ZEN-Ub1 created a deletion of size 21166bp between positions 63262838-63284003 of Chromosome 4 (Build GRCm39). Orm1, Orm2, Orm3 genes are said to be very tightly linked and would all be knocked out in this mouse line. Orm1, Orm2, and Orm3 mRNA are not detected in the liver. (J:136110, J:292194)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 1 line available
• Carrying any Orm2 Mutation: 12 strains or lines available

References

• Original: J:136110 Velocigene, Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals). MGI Direct Data Submission. 2008
• All: 4 reference(s)