Sgpp1^{tm1(KOMP)Vlcg}
Targeted Allele Detail

Summary

• Symbol: Sgpp1^{tm1(KOMP)Vlcg}
• Name: sphingosine-1-phosphate phosphatase 1; targeted mutation 1, Velocigene
• MGI ID: MGI:3808500
• Synonyms: Sgpp1^tm1Vlcg
• Gene: Sgpp1 Location: Chr12:75761023-75782503 bp, - strand Genetic Position: Chr12, 32.95 cM
• Alliance: Sgpp1^{tm1(KOMP)Vlcg} page
• IMPC: Sgpp1 gene page

Sgpp1^{tm1(KOMP)Vlcg}/Sgpp1^{tm1(KOMP)Vlcg} pups exhibit focal desquamation and abnormal epidermal histology

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Mutant Cell Lines: 10963C-C9, 10963C-E3, 10963C-F1, 10963C-G12
• Germline Transmission: Earliest citation of germline transmission: J:199597
• Parent Cell Line: VGB6 (ES Cell)
• Strain of Origin: C57BL/6NTac
• Project Collection: KOMP-Regeneron

Mutation description

Allele Type: Targeted (Null/knockout, Reporter) Mutations: Insertion, Intragenic deletion Vector: ZEN-Ub1 Mutation details: The insertion of Velocigene cassette ZEN-Ub1 created a deletion of size 19624bp between positions 75762711-75782334 of Chromosome 12 (Build GRCm39). The lacZ and neomycin resistance cassette replaced the entire coding region from exon 1 to 3. (J:136110, J:199597)

Generation of the Sgpp1^tm1(KOMP)Vlcg allele

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 1 line available
• Carrying any Sgpp1 Mutation: 25 strains or lines available

References

• Original: J:136110 Velocigene, Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals). MGI Direct Data Submission. 2008
• All: 3 reference(s)