Zfp568^{Gt(RRU161)Byg}
Gene trapped Allele Detail

Summary

• Symbol: Zfp568^{Gt(RRU161)Byg}
• Name: zinc finger protein 568; gene trap RRU161, BayGenomics
• MGI ID: MGI:3808700
• Synonyms: Zfp568^null
• Gene: Zfp568 Location: Chr7:29683380-29727707 bp, + strand Genetic Position: Chr7, 17.26 cM
• Alliance: Zfp568^{Gt(RRU161)Byg} page

Mutation origin

• Mutant Cell Line: RRU161
• Germline Transmission: Earliest citation of germline transmission: J:139139
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout)
• Mutation: Insertion of gene trap vector Vector: pGT0Lxf Vector Type: gene trap
• Mutation details: A gene trap vector containing neo gene selection cassette was inserted into the Zfp568 gene resulting in abnormal splicing to an acceptor site in the vector insert from the first coding exon of the Zfp568 gene. Fusion protein contains 11 amino acids from Zfp568 followed by 19 amino acids that do not contain any recognizable functional domain. It is a null allele. (J:139139)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  RRU161	CL265342 ; (MGI Seq Detail)	5' RACE	Chr7:29684709-29687228 bp (+)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  183 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zfp568 Mutation: 128 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

• Original: J:139139 Garcia-Garcia MJ, et al., Chato, a KRAB zinc-finger protein, regulates convergent extension in the mouse embryo. Development. 2008 Sep;135(18):3053-62
• All: 3 reference(s)