Pofut1^tm1Ysa
Targeted Allele Detail

Summary

• Symbol: Pofut1^tm1Ysa
• Name: protein O-fucosyltransferase 1; targeted mutation 1, Yumiko Saga
• MGI ID: MGI:3808704
• Gene: Pofut1 Location: Chr2:153083453-153112167 bp, + strand Genetic Position: Chr2, 75.41 cM, cytoband H2
• Alliance: Pofut1^tm1Ysa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:139209
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 1 and an frt-flanked neo cassette with a 5' loxP site was inserted downstream of exon 1. Germ line, flp mediated recombination was used to remove the neo cassette. (J:139209)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pofut1 Mutation: 22 strains or lines available

References

• Original: J:139209 Okamura Y, et al., Pofut1 is required for the proper localization of the Notch receptor during mouse development. Mech Dev. 2008 Aug;125(8):663-73
• All: 3 reference(s)