Ascl3^{tm1(EGFP/cre)Ovi}
Targeted Allele Detail

Summary

• Symbol: Ascl3^{tm1(EGFP/cre)Ovi}
• Name: achaete-scute family bHLH transcription factor 3; targeted mutation 1, Catherine E Ovitt
• MGI ID: MGI:3808720
• Synonyms: Ascl3^EGFP-Cre
• Gene: Ascl3 Location: Chr7:109326672-109330933 bp, - strand Genetic Position: Chr7, 57.46 cM
• Alliance: Ascl3^{tm1(EGFP/cre)Ovi} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:139151
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutations: Insertion, Intragenic deletion
• Ascl3^{tm1(EGFP/cre)Ovi} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Ascl3 (MGI:1928820)

• Mutation details: Exon 2, which contains the entire coding region of the gene, was replaced by targeting vector consisting of an EGFP/Cre-recombinase fusion gene followed by a floxed neomycin selection cassette. This targeting event generates a null allele. The EGFP/Cre-recombinase fusion product was detected in duct cells of the submandibular, sublingual and parotid glands. (J:139151)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Ascl3 (mouse) Summary of all recombinase alleles driven by Ascl3. Comparative matrix view of recombinase activities Alliance mouse Ascl3 gene page

Expression

In Mice Carrying this Mutation:

14 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ascl3 Mutation: 9 strains or lines available

References

• Original: J:139151 Bullard T, et al., Ascl3 expression marks a progenitor population of both acinar and ductal cells in mouse salivary glands. Dev Biol. 2008 Aug 1;320(1):72-8
• All: 3 reference(s)