Col2a1^Rgsc856
Chemically induced Allele Detail

Summary

• Symbol: Col2a1^Rgsc856
• Name: collagen, type II, alpha 1; RIKEN Genomic Sciences Center (GSC), 856
• MGI ID: MGI:3808759
• Synonyms: M100856
• Gene: Col2a1 Location: Chr15:97873483-97902525 bp, - strand Genetic Position: Chr15, 53.97 cM
• Alliance: Col2a1^Rgsc856 page

Skeletal abnormalities in Col2a1^Rgsc856/Col2a1⁺ and Col2a1^Rgsc856/Col2a1^Rgsc856 mice at E18.5

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C57BL/6JJcl
• Project Collection: RIKEN GSC ENU Project

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU induced an A to C missense mutation at position 4406 which is predicted to cause an aspartic acid to alanine substitution at position 1469. This mutation is located in the coding region of the C-propeptide. (J:171906)
• Inheritance: Dominant

Disease models

Expression

In Structures Affected by this Mutation:

14 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Col2a1 Mutation: 69 strains or lines available

References

• Original: J:133634 RIKEN BioResource Center/RIKEN Genomic Sciences Center, A Large Scale Mutagenesis Program in RIKEN GSC. PhenoSITE, World Wide Web (URL: http://www.brc.riken.jp/lab/gsc/mouse/). 2008
• All: 2 reference(s)