Ikbkg^m1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Ikbkg^m1Btlr
• Name: inhibitor of kappaB kinase gamma; mutation 1, Bruce Beutler
• MGI ID: MGI:3808877
• Synonyms: panr2, pan resistance 2
• Gene: Ikbkg Location: ChrX:73436896-73497460 bp, + strand Genetic Position: ChrX, 38.0 cM
• Alliance: Ikbkg^m1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: This mutation was identified in a toll-like receptor (TLR) signaling screen of G3 progeny of an ENU mutagenized male mouse. It comprises a T to C transition at nucleotide position 473, in the fourth of ten total exons, that results in replacement of a highly conserved leucine by proline at amino acid position 153 of the protein (L153P; variant 1, Genbank: NM_178590), in the first coiled-coil (CC1) domain. (J:139558)
• Inheritance: Other (see notes)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ikbkg Mutation: 16 strains or lines available

Notes

The phenotype associated with this allele is transmitted in an X-linked semidominant manner.

References

• Original: J:139558 Siggs OM, et al., Record for "panr2" updated September 19th, 2008. MGI Direct Data Submission. 2008
• All: 3 reference(s)