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Itgb2M1Btlr
Chemically induced Allele Detail
Summary
Symbol: Itgb2M1Btlr
Name: integrin beta 2; mutation 1, Bruce Beutler
MGI ID: MGI:3808883
Synonyms: Itgb2Jkr, Joker
Gene: Itgb2  Location: Chr10:77366164-77401542 bp, + strand  Genetic Position: Chr10, 39.72 cM
Alliance: Itgb2M1Btlr page
Mutation
origin
Strain of Origin:  C57BL/6J
Project Collection: Beutler Mutagenetix
Mutation
description
Allele Type:    Chemically induced (ENU)
Mutation:    Single point mutation
 
Mutation detailsThis mutation comprises an A to T transversion in the intron 6 acceptor splice site (TCCCAG->TCCCTG), at nucleotide position 19597 of the gene sequence (Genbank NC_000076). The mutation is predicted to result in the in-frame deletion from the mature transcript of the entire 155 bp seventh exon. Neither cell surface nor intracellular staining with antibodies to integrin beta 2 detects the protein in homozygous mutant mice. (J:139559)
Inheritance:    Semidominant
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Itgb2 Mutation:  50 strains or lines available
Notes
CD11 subunits (CD11a, CD11b and/or CD11c) are not detected on any cell type examined from homozygous mutant mice. NK cells from heterozygous mutant mice display CD11b at a level intermediate between those of wild-type and of homozygous mutant NK cells. (J:139559)
References
Original:  J:139559 Crozat K, et al., Joker is a splice-site mutation of integrin beta 2 (Itgb2). MGI Direct Data Submission. 2008;
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory