About   Help   FAQ
Itgb2M1Btlr
Chemically induced Allele Detail
Summary
Symbol: Itgb2M1Btlr
Name: integrin beta 2; mutation 1, Bruce Beutler
MGI ID: MGI:3808883
Synonyms: Itgb2Jkr, Joker
Gene: Itgb2  Location: Chr10:77366164-77401542 bp, + strand  Genetic Position: Chr10, 39.72 cM
Alliance: Itgb2M1Btlr page
Mutation
origin
Strain of Origin:  C57BL/6J
Project Collection: Beutler Mutagenetix
Mutation
description
Allele Type:    Chemically induced (ENU)
Mutation:    Single point mutation
 
Mutation detailsThis mutation comprises an A to T transversion in the intron 6 acceptor splice site (TCCCAG->TCCCTG), at nucleotide position 19597 of the gene sequence (Genbank NC_000076). The mutation is predicted to result in the in-frame deletion from the mature transcript of the entire 155 bp seventh exon. Neither cell surface nor intracellular staining with antibodies to integrin beta 2 detects the protein in homozygous mutant mice. (J:139559)
Inheritance:    Semidominant
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Itgb2 Mutation:  50 strains or lines available
Notes
CD11 subunits (CD11a, CD11b and/or CD11c) are not detected on any cell type examined from homozygous mutant mice. NK cells from heterozygous mutant mice display CD11b at a level intermediate between those of wild-type and of homozygous mutant NK cells. (J:139559)
References
Original:  J:139559 Crozat K, et al., Joker is a splice-site mutation of integrin beta 2 (Itgb2). MGI Direct Data Submission. 2008;
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
10/29/2024
MGI 6.24
The Jackson Laboratory