Fmr1^tm1.2Cidz
Targeted Allele Detail

Summary

• Symbol: Fmr1^tm1.2Cidz
• Name: fragile X messenger ribonucleoprotein 1; targeted mutation 1.2, Chris I de Zeeuw
• MGI ID: MGI:3808885
• Synonyms: Fmr1 KO2
• Gene: Fmr1 Location: ChrX:67722147-67761569 bp, + strand Genetic Position: ChrX, 34.83 cM
• Alliance: Fmr1^tm1.2Cidz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:108008
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A germline null mutation was created by crossing Fmr1 mice, which have the first coding exon floxed, with mice that express cre-recombinase in the germline (Tg(CAG-cre)13Miya). Gene inactivation was confirmed by a lack of protein expression in the brain and testes as determined by immunoblot analysis. (J:108008)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fmr1 Mutation: 29 strains or lines available

References

• Original: J:108008 Mientjes EJ, et al., The generation of a conditional Fmr1 knock out mouse model to study Fmrp function in vivo. Neurobiol Dis. 2006 Mar;21(3):549-55
• All: 48 reference(s)