Rbpj^tm1Rsch
Targeted Allele Detail

Summary

• Symbol: Rbpj^tm1Rsch
• Name: recombination signal binding protein for immunoglobulin kappa J region; targeted mutation 1, Roland Schmid
• MGI ID: MGI:3809241
• Synonyms: Rbpj^f
• Gene: Rbpj Location: Chr5:53713121-53814787 bp, + strand Genetic Position: Chr5, 29.37 cM, cytoband C1-C3
• Alliance: Rbpj^tm1Rsch page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:139250
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 6 and a floxed neo cassette was inserted downstream of exon 7. The neo cassette was removed by cre mediated recombination following transient expression of cre in ES cells. Exon 6 and 7 encode the DNA-binding domain. (J:139250)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rbpj Mutation: 193 strains or lines available

References

• Original: J:139250 Nakhai H, et al., Conditional ablation of Notch signaling in pancreatic development. Development. 2008 Aug;135(16):2757-65
• All: 6 reference(s)