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Rbpjtm1Rsch
Targeted Allele Detail
Summary
Symbol: Rbpjtm1Rsch
Name: recombination signal binding protein for immunoglobulin kappa J region; targeted mutation 1, Roland Schmid
MGI ID: MGI:3809241
Synonyms: Rbpjf
Gene: Rbpj  Location: Chr5:53713121-53814787 bp, + strand  Genetic Position: Chr5, 29.37 cM, cytoband C1-C3
Alliance: Rbpjtm1Rsch page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:139250
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Conditional ready)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 6 and a floxed neo cassette was inserted downstream of exon 7. The neo cassette was removed by cre mediated recombination following transient expression of cre in ES cells. Exon 6 and 7 encode the DNA-binding domain. (J:139250)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rbpj Mutation:  193 strains or lines available
References
Original:  J:139250 Nakhai H, et al., Conditional ablation of Notch signaling in pancreatic development. Development. 2008 Aug;135(16):2757-65
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory