Dicer1^tm1Snj
Targeted Allele Detail

Summary

• Symbol: Dicer1^tm1Snj
• Name: dicer 1, ribonuclease type III; targeted mutation 1, Stephen N Jones
• MGI ID: MGI:3809260
• Synonyms: Dicer^c
• Gene: Dicer1 Location: Chr12:104654001-104718211 bp, - strand Genetic Position: Chr12, 54.83 cM, cytoband E-F1
• Alliance: Dicer1^tm1Snj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:139257
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neo cassette was inserted upstream of exon 15 and an additional loxP site was inserted downstream of exon 17. Germ line, cre mediated recombination was used to remove the neo cassette. (J:139257)

Disease models

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dicer1 Mutation: 96 strains or lines available

References

• Original: J:139257 Mudhasani R, et al., Loss of miRNA biogenesis induces p19Arf-p53 signaling and senescence in primary cells. J Cell Biol. 2008 Jun 30;181(7):1055-63
• All: 6 reference(s)