Dicer1^tm1.1Snj
Targeted Allele Detail

Summary

• Symbol: Dicer1^tm1.1Snj
• Name: dicer 1, ribonuclease type III; targeted mutation 1.1, Stephen N Jones
• MGI ID: MGI:3809262
• Synonyms: Dicer^deltaC
• Gene: Dicer1 Location: Chr12:104654001-104718211 bp, - strand Genetic Position: Chr12, 54.83 cM, cytoband E-F1
• Alliance: Dicer1^tm1.1Snj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:139257
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Cre recombination in ES cells was used to remove exons 15 through 17, which encode the PAZ domain. (J:139257)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dicer1 Mutation: 96 strains or lines available

References

• Original: J:139257 Mudhasani R, et al., Loss of miRNA biogenesis induces p19Arf-p53 signaling and senescence in primary cells. J Cell Biol. 2008 Jun 30;181(7):1055-63
• All: 2 reference(s)