Tmprss6^tm1Otin
Targeted Allele Detail

Summary

• Symbol: Tmprss6^tm1Otin
• Name: transmembrane serine protease 6; targeted mutation 1, Carlos Lopez-Otin
• MGI ID: MGI:3809291
• Gene: Tmprss6 Location: Chr15:78323867-78352834 bp, - strand Genetic Position: Chr15, 37.49 cM, cytoband E2
• Alliance: Tmprss6^tm1Otin page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:138734
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A cassette containing a puromycin resistance gene, an Hprt minigene, and an agouti minigene was inserted 3' of exon 6. Following this insert, exons 3-6 were duplicated. Northern blot analysis indicated the complete absensence of mRNA transcribed from this allele in liver RNA. (J:138734)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tmprss6 Mutation: 46 strains or lines available

References

• Original: J:138734 Folgueras AR, et al., Membrane-bound serine protease matriptase-2 (Tmprss6) is an essential regulator of iron homeostasis. Blood. 2008 Sep 15;112(6):2539-45
• All: 14 reference(s)