Hcn4^{tm1(cre/ERT2)Anlu}
Targeted Allele Detail

Summary

• Symbol: Hcn4^{tm1(cre/ERT2)Anlu}
• Name: hyperpolarization-activated, cyclic nucleotide-gated K+ 4; targeted mutation 1, Andreas Ludwig
• MGI ID: MGI:3809312
• Synonyms: HCN4-KiT, HCN4KiT-Cre, Hcn4^{tm1(cre/ESR1)Anlu}
• Gene: Hcn4 Location: Chr9:58730695-58770458 bp, + strand Genetic Position: Chr9, 31.8 cM, cytoband C
• Alliance: Hcn4^{tm1(cre/ERT2)Anlu} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:139266
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Hcn4^{tm1(cre/ERT2)Anlu} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Hcn4 (MGI:1298209)

• Mutation details: A cre/ERT2 fusion gene and a neo cassette were inserted into exon 1 downstream of the translation initiation codon. Expression is tamoxifen inducible and localized to the superior vena cava in the proximity of the right atrial appendage and the aorta, specifically in the sinoatrial and atrioventricular nodes. (J:139266)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Hcn4 (mouse) Summary of all recombinase alleles driven by Hcn4. Comparative matrix view of recombinase activities Alliance mouse Hcn4 gene page

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hcn4 Mutation: 67 strains or lines available

References

• Original: J:139266 Hoesl E, et al., Tamoxifen-inducible gene deletion in the cardiac conduction system. J Mol Cell Cardiol. 2008 Jul;45(1):62-9
• All: 10 reference(s)