Nuak2^tm1Esu
Targeted Allele Detail

Summary

• Symbol: Nuak2^tm1Esu
• Name: NUAK family, SNF1-like kinase, 2; targeted mutation 1, Hiroyasu Esumi
• MGI ID: MGI:3809459
• Synonyms: Snark^-
• Gene: Nuak2 Location: Chr1:132243864-132261226 bp, + strand Genetic Position: Chr1, 57.24 cM, cytoband E4
• Alliance: Nuak2^tm1Esu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:139603
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced with a tk-Neo selection cassette. As a result, mRNA expression was completely abolished in mouse embryo fibroblasts isolated at E13.5. (J:139603)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nuak2 Mutation: 32 strains or lines available

References

• Original: J:139603 Tsuchihara K, et al., Susceptibility of Snark-deficient mice to azoxymethane-induced colorectal tumorigenesis and the formation of aberrant crypt foci. Cancer Sci. 2008 Apr;99(4):677-82
• All: 4 reference(s)