Sox2^tm1Okud
Targeted Allele Detail

Summary

• Symbol: Sox2^tm1Okud
• Name: SRY (sex determining region Y)-box 2; targeted mutation 1, Akihiko Okuda
• MGI ID: MGI:3809487
• Synonyms: Sox2^FL
• Gene: Sox2 Location: Chr3:34704554-34706610 bp, + strand Genetic Position: Chr3, 16.93 cM, cytoband A2-B
• Alliance: Sox2^tm1Okud page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:138323
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutations: Insertion, Intragenic deletion
• The mouse Sox2 ORF was replaced with IREShygTKpA cassette flanked by loxP sites. (J:138323)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sox2 Mutation: 56 strains or lines available

References

• Original: J:138323 Miyagi S, et al., Consequence of the loss of Sox2 in the developing brain of the mouse. FEBS Lett. 2008 Aug 6;582(18):2811-5
• All: 2 reference(s)