Bdnf^tm1Meg
Targeted Allele Detail

Summary

• Symbol: Bdnf^tm1Meg
• Name: brain derived neurotrophic factor; targeted mutation 1, Micheal E Greenberg
• MGI ID: MGI:3809491
• Synonyms: BdnfIV^-
• Gene: Bdnf Location: Chr2:109505045-109557352 bp, + strand Genetic Position: Chr2, 56.63 cM
• Alliance: Bdnf^tm1Meg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:139381
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted
• Mutation: Intragenic deletion
• Mutation details: The non-coding exon IV plus some promoter sequence was deleted from nucleotides -160 to +281 relative to the transcription initiation start site. Basal synthesis of the gene product was unaffected but translation of the gene in neurons did not increase in response to Ca²⁺ influx. (J:139381)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bdnf Mutation: 42 strains or lines available

References

• Original: J:139381 Singh KK, et al., Developmental axon pruning mediated by BDNF-p75NTR-dependent axon degeneration. Nat Neurosci. 2008 Jun;11(6):649-58
• All: 1 reference(s)