Creb1tm1Jsca
Targeted Allele Detail
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Symbol: |
Creb1tm1Jsca |
Name: |
cAMP responsive element binding protein 1; targeted mutation 1, J Simon C Arthur |
MGI ID: |
MGI:3809580 |
Synonyms: |
CREB DN, CrebS133A |
Gene: |
Creb1 Location: Chr1:64571963-64643707 bp, + strand Genetic Position: Chr1, 32.74 cM, cytoband C1/C5
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Alliance: |
Creb1tm1Jsca page
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Germline Transmission: |
Earliest citation of germline transmission:
J:139576
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Inserted expressed sequence) |
Mutation: |
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Insertion
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Mutation details: A minigene consisting of wild-type exon 4 fused to the downstream exons of this gene locus was used in a targeting vector. The minigene and a neo-selection cassette were flanked with loxP sites and placed upstream of a mutated exon 4 sequence that substitutes the serine at amino acid 133 to an Alanine. This targeting vector was used to replace the endogenous exon 4 of the gene locus. In the absence of Cre expression, splicing between exon 3 and the minigene results in expression of a wild-type protein. Following expression of Cre-recombinase, the minigene is removed and splicing occurs on to the mutated exon 4 leading to transcription of the Ser133Ala mutant.
(J:139576)
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Generation of a Chd6 Exon 12 -/- mouse line. |
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Creb1 Mutation: |
61 strains or lines available
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Original: |
J:139576 Ananieva O, et al., The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling. Nat Immunol. 2008 Sep;9(9):1028-36 |
All: |
10 reference(s) |
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