Ano1^tm1Bdh
Targeted Allele Detail

Summary

• Symbol: Ano1^tm1Bdh
• Name: anoctamin 1, calcium activated chloride channel; targeted mutation 1, Brian D Harfe
• MGI ID: MGI:3809591
• Synonyms: Ano1^tm1Jrr, TMEM16A^-, Tmem16a^tm1Bdh
• Gene: Ano1 Location: Chr7:144142286-144305711 bp, - strand Genetic Position: Chr7, 88.85 cM
• Alliance: Ano1^tm1Bdh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:138613
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 12 was replaced with a neo cassette. This deletion results in a frame shift and a premature stop codon 40 amino acids downstream of the deletion. Seven of the eight transmembrane domains are disrupted due to this frame shift. (J:138613)

Expression

In Mice Carrying this Mutation:	15 assay results
In Structures Affected by this Mutation:	8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ano1 Mutation: 60 strains or lines available

References

• Original: J:138613 Rock JR, et al., The transmembrane protein TMEM16A is required for normal development of the murine trachea. Dev Biol. 2008 Sep 1;321(1):141-9
• All: 21 reference(s)