Rigi^tm1Zgwg
Targeted Allele Detail

Summary

• Symbol: Rigi^tm1Zgwg
• Name: RNA sensor RIG-I; targeted mutation 1, Zhugang Wang
• MGI ID: MGI:3809597
• Synonyms: Rigi^-, Rig-I^-
• Gene: Rigi Location: Chr4:40203773-40239828 bp, - strand Genetic Position: Chr4, 20.24 cM
• Alliance: Rigi^tm1Zgwg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:139868
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 4 through 8 were replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on splenocyte extracts with or without treatment with LPS. (J:139868)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rigi Mutation: 55 strains or lines available

References

• Original: J:139868 Wang Y, et al., Rig-I-/- mice develop colitis associated with downregulation of G alpha i2. Cell Res. 2007 Oct;17(10):858-68
• All: 18 reference(s)